Wednesday, January 6, 2016

USMLE bacterial virulence, this is from a microbiology source, not First Aid or Uworld.

TABLE 2. EXAMPLES OF SPECIFIC ATTACHMENTS OF BACTERIA TO HOST CELL OR TISSUE SURFACES
BacteriumAdhesinReceptorAttachment siteDisease
Streptococcus pyogenesProtein FAmino terminus of fibronectinPharyngeal epitheliumSore throat
Streptococcus mutansGlycosyl transferaseSalivary glycoproteinPellicle of toothDental caries
Streptococcus salivariusLipoteichoic acidUnknown Buccal epithelium of tongue None
Streptococcus pneumoniaeCell-bound proteinN-acetylhexos-
amine-galactose disaccharide
Mucosal epitheliumpneumonia
Staphylococcus aureusCell-bound proteinAmino terminus of fibronectinMucosal epitheliumVarious
Neisseria gonorrhoeaeType IV pili (N-methylphenyl- alanine pili)Glucosamine-
galactose carbohydrate
Urethral/
cervical epithelium
Gonorrhea
Enterotoxigenic E. coliType-I fimbriaeSpecies-specific carbohydrate(s) Intestinal epitheliumDiarrhea
UropathogenicE. coliType I fimbriaeComplex carbohydrateUrethral epitheliumUrethritis
UropathogenicE. coliP-pili (pap)Globobiose linked to ceramide lipidUpper urinary tractPyelonephritis
Bordetella pertussisFimbriae ("filamentous hemagglutinin")Galactose on sulfated glycolipidsRespiratory epitheliumWhooping cough
Vibrio choleraeN-methylphenyl-
alanine pili
Fucose and mannose carbohydrateIntestinal epitheliumCholera
Treponema pallidumPeptide in outer membraneSurface protein (fibronectin)Mucosal epitheliumSyphilis
MycoplasmaMembrane proteinSialic acidRespiratory epithelium Pneumonia
ChlamydiaUnknownSialic acidConjunctival or urethral epitheliumConjunctivitis or urethritis


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